Juana Enríquez

Juana Enriquez, 5th Lady of Casarrubios del Monte (1425 – 13 February 1468) was Queen of Aragon and de facto Queen consort of Navarre as the wife of King John II. Juana Enríquez was the Regent of Navarre during the absence of her husband in the Navarrese Civil War (1451–1455); she also served as Governor of Catalonia in 1462 in the place of her son (who was his father's nominal governor) and, finally, as Regent of Aragon during the absence of her husband in the Catalan Civil War between 1465 and 1468.

Source: Wikipedia — https://en.wikipedia.org/wiki/Juana_Enr%C3%ADquez